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Effect of chronic upregulation of endocannabinoid signaling <i>in vivo</i> with JZL184 on striatal synaptic plasticity and motor learning in YAC128 Huntington disease mice

2024-09-27

Abstract excerpt

<h4>ABSTRACT</h4> Synaptic dysfunction underlies early sensorimotor and cognitive deficits, and precedes neurodegeneration in a variety of disorders, including Alzheimer, Parkinson and Huntington disease (HD). A monogenic inherited disorder, HD manifests with cognitive, motor and mood disorders associated with progressive degeneration of striatal spiny projection neurons and cortical pyramidal neurons. Cortico-ba...

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Literature Corpus work: 13d344ef-5154-5f8e-a1a6-fd7eaafd6dee
DOI: 10.1101/2024.09.25.614804

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Effect of chronic upregulation of endocannabinoid signaling <i>in vivo</i> with JZL184 on striatal synaptic plasticity and motor learning in YAC128 Huntington disease miceDOI 10.1101/2024.09.25.614804Read

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