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Article

Environmental enrichment slows disease progression in R6/2 Huntington's disease mice.

Annals of neurology - 1 Feb 2002

Hockly Emma, Cordery Patricia M, Woodman Benjamin, Mahal Amarbirpal, van Dellen Anton, Blakemore Colin, Lewis Cathryn M, Hannan Anthony J, Bates Gillian P

Abstract excerpt

Huntington's disease is a genetic disorder that causes motor dysfunction, personality changes, dementia, and premature death. There is currently no effective therapy. Several transgenic models of Huntington's disease are available, the most widely used of which is the R6/2 mouse, because of its rapid disease progression. Environmental enrichment alters gene expression in the normal mouse brain, and modulates the...

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PMID: 11835380
DOI: 10.1002/ana.10094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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