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Article

Altered excitability and exocytosis in chromaffin cells from the R6/1 mouse model of Huntington's disease is linked to over-expression of mutated huntingtin.

Journal of neurochemistry - 1 Nov 2018

Martínez-Ramírez Carmen, Baraibar Andrés M, Nanclares Carmen, Méndez-López Iago, Gómez Ana, Muñoz Mᵃ Paz, de Diego Antonio M G, Gandía Luis, Casarejos María José, García Antonio G

Abstract excerpt

As the peripheral sympathoadrenal axis is tightly controlled by the cortex via hypothalamus and brain stem, the central pathological features of Hunting's disease, (HD) that is, deposition of mutated huntingtin and synaptic dysfunctions, could also be expressed in adrenal chromaffin cells. To test this hypothesis we here present a thorough investigation on the pathological and functional changes undergone by...

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PMID: 30182387
DOI: 10.1111/jnc.14585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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