Article

Identification of the key role of white matter alteration in the pathogenesis of Huntington’s Disease

2021-06-22

Abstract excerpt

Pathogenesis of the inherited neurodegenerative disorder Huntington’s Disease (HD) is complex and progressive, with a long presymptomatic phase in which subtle changes occur in the brain of gene carriers up to 15 years before the onset of symptoms. Thus, there is a need of early, functional biomarker to better understand disease progression and to evaluate treatment efficacy far from onset. In particular, recent s...

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Literature Corpus work: 95f4c25f-3840-5b9c-a8d9-f4039189f1bc
DOI: 10.1101/2021.06.21.449242

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