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Article

Synaptic RTP801 contributes to motor-learning dysfunction in Huntington’s disease

30 Jul 2020

Abstract excerpt

RTP801/REDD1 is a stress-responsive protein that mediates mutant huntingtin (mhtt) toxicity in cellular models and is up regulated in Huntington's disease (HD) patients' putamen. Here, we investigated whether RTP801 is involved in motor impairment in HD by affecting striatal synaptic plasticity. To explore this hypothesis, ectopic mhtt was over expressed in cultured rat primary neurons. Moreover, the protein...

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PMID: 32732871
DOI: 10.1038/s41419-020-02775-5

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