Article

Metformin antiproliferative activity is exclusively mediated by the membrane functional expression of the Chloride Intracellular Channel 1 in glioblastoma stem cells

2022-12-31

Abstract excerpt

Metformin is the first-line drug for type-2 diabetes. Retrospective analyses, based on diabetic patients’ clinical data, demonstrate that daily assumption of metformin reduces the incidence of several kinds of solid tumors. Even though it is widely agreed that metformin must be internalized to accomplish its pharmacological activity, direct evidence about metformin membrane permeability and/or the presence of a sp...

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Literature Corpus work: 047286e6-9a76-5adc-9227-84b58c275386
DOI: 10.1101/2022.12.31.522371

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