Article

Transmembrane CLIC1 sustains EGFRvIII–STAT3 oncogenic signaling in Glioblastoma through interaction with OSMR

2025-05-05

Abstract excerpt

<title>Abstract</title> <p>Oncostatin M receptor (OSMR) plays diverse and important roles in several human malignancies, including brain, breast, and pancreatic cancer<sup>1-4</sup>. Glioblastoma (GB) is the most malignant genetically diverse brain tumour, with no cure. The most common genetic mutation in GB is a truncated active mutant of epidermal growth factor receptor (EGFR), the EGFRvIII. OSMR orchestrates a...

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Literature Corpus work: 9b300eb3-818a-5cf1-8ede-4389061d8a15
DOI: 10.21203/rs.3.rs-6537096/v1

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