Article

The anticancer effect of Metformin targets VDAC1 via ER-mitochondria interaction-mediated autophagy in HCC

2024-05-14

Abstract excerpt

<title>Abstract</title> <p>Metformin (MetF) is widely used worldwide as a first-line therapy for type 2 diabetes. Recently, there has been increasing interest in the pleiotropic effects of MetF, such as its anti-cancer and anti-aging properties. However, the molecular target of the MetF and the detailed mechanism underlying its cell growth inhibitory effects through autophagy induction remain incompletely elucida...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2a5b078e-5007-57cd-8db5-9c0b765e7f1a
DOI: 10.21203/rs.3.rs-4350478/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The anticancer effect of Metformin targets VDAC1 via ER-mitochondria interaction-mediated autophagy in HCCDOI 10.21203/rs.3.rs-4350478/v1Read

Metformin antiproliferative activity is exclusively mediated by the membrane functional expression of the Chloride Intracellular Channel 1 in glioblastoma stem cellsSemantic proximity Read

Metformin: an old drug with potential therapeutic function in antitumorSemantic proximity Read

Role of human organic cation transporter-1 (OCT-1/SLC22A1) in modulating the response to metformin in patients with type 2 diabetes.Semantic proximity Read

Substrate binding and lipid-mediated allostery in the human organic anion transporter 1 at the atomic-scaleSemantic proximity Read

PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain.Semantic proximity Read

Role of the plasma membrane transporter of organic cations OCT1 and its genetic variants in modern liver pharmacology.Semantic proximity Read

Function and therapeutic potential of metformin in multiple diseasesSemantic proximity Read

Effects of metformin on cancers in experimental and clinical studies: Focusing on autophagy and AMPK/mTOR Signaling PathwaysSemantic proximity Read

Mitochondria‐associated endoplasmic reticulum membrane: Overview and inextricable link with cancerSemantic proximity Read

Targeting Lysosomal MCOLN1/TRPML1 Ion Channels to Finely Alleviate Diabetes Mellitus via a Ca <sup>2+</sup> - CaMKKβ-AMPK pathwaySemantic proximity Read

Repositioning metformin in cancer: genetics, drug targets, and new ways of delivery.Semantic proximity Read

Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancerSemantic proximity Read