Article

An OSMR-CLIC1 cross talk drives key oncogenic pathways in glioblastoma

2025-03-10

Abstract excerpt

Oncostatin M receptor (OSMR) plays diverse and important roles in several human malignancies, including brain, breast, and pancreatic cancer. 1–4 Glioblastoma (GB) is the most malignant genetically diverse brain tumour, with no cure. The most common genetic mutation in GB is a truncated active mutant of epidermal growth factor receptor (EGFR), the EGFRvIII. OSMR orchestrates a feedforward signaling mechanism with...

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Literature Corpus work: 94d8bf53-f1af-5070-b029-fe2f1e61c68b
DOI: 10.1101/2025.03.05.641563

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