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Article

Repositioning metformin in cancer: genetics, drug targets, and new ways of delivery.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jun 2014

Aldea Mihaela, Craciun Lucian, Tomuleasa Ciprian, Berindan-Neagoe Ioana, Kacso Gabriel, Florian Ioan Stefan, Crivii Carmen

Abstract excerpt

After sitting many years on the shelves of drug stores as a harmless antidiabetic drug, metformin comes back in the spotlight of the scientific community as a surprisingly effective antineoplastic drug. Metformin targets multiple pathways that play pivotal roles in cancer progression, impacting various cellular processes, such as proliferation, cell death, metabolism, and even the cancer stemness features. The...

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PMID: 24504677
DOI: 10.1007/s13277-014-1676-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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