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Loss of Y and clonal hematopoiesis in blood—two sides of the same coin?

1 Nov 2021

Abstract excerpt

Studies in recent years have revealed that increasing age is associated with the accumulation of post-zygotic genetic aberrations in different cell lineages even in the absence of active malignancy. Clonal hematopoiesis of indeterminate potential (CHIP) is defined as the detection of somatic mutations in genes commonly associated with myeloid neoplasms in the peripheral blood of individuals with no sign of...

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PMID: 34725452
DOI: 10.1038/s41375-021-01456-2

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