Article
De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts.
Proceedings of the National Academy of Sciences of the United States of America - 22 Oct 2013
Zhu Jiang, Wu Xueling, Zhang Baoshan, McKee Krisha, O'Dell Sijy, Soto Cinque, Zhou Tongqing, Casazza Joseph P, Mullikin James C, Kwong Peter D, Mascola John R, Shapiro Lawrence
Abstract excerpt
Next-generation sequencing of antibody transcripts provides a wealth of data, but the ability to identify function-specific antibodies solely on the basis of sequence has remained elusive. We previously characterized the VRC01 class of antibodies, which target the CD4-binding site on gp120, appear in multiple donors, and broadly neutralize HIV-1. Antibodies of this class have developmental commonalities, but...
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