Article
VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.
Cell host & microbe - 8 Apr 2020
Shen Chen-Hsiang, DeKosky Brandon J, Guo Yicheng, Xu Kai, Gu Ying, Kilam Divya, Ko Sung Hee, Kong Rui, Liu Kevin, Louder Mark K, Ou Li, Zhang Baoshan, Chao Cara W, Corcoran Martin M, Feng Eric, Huang Jesse, Normandin Erica, O'Dell Sijy, Ransier Amy, Rawi Reda, Sastry Mallika, Schmidt Stephen D, Wang Shuishu, Wang Yiran, Chuang Gwo-Yu, Doria-Rose Nicole A, Lin Bob, Zhou Tongqing, Boritz Eli A, Connors Mark, Douek Daniel C, Karlsson Hedestam Gunilla B, Sheng Zizhang, Shapiro Lawrence, Mascola John R, Kwong Peter D
Abstract excerpt
Rare mutations have been proposed to restrict the development of broadly neutralizing antibodies against HIV-1, but this has not been explicitly demonstrated. We hypothesized that such rare mutations might be identified by comparing broadly neutralizing and non-broadly neutralizing branches of an antibody-developmental tree. Because sequences of antibodies isolated from the fusion peptide (FP)-targeting...
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