Article

Cell engulfment defines spatially distinct competitive metabolic niches associated with clinical outcomes in colorectal cancer

2025-07-18

Abstract excerpt

Cell competition is an emerging mechanism in which mammalian tissues maintain homeostasis by eliminating less fit (loser) cells through direct interactions with fitter (winner) neighbouring cells. In cancer, these competitive interactions may drive tumour evolution; however, spatial organisation and clinical relevance of these events remain poorly understood. One mechanism by which winner cells eliminate loser cel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 03fb20d3-0539-595b-89bb-e3d26f23357a
DOI: 10.1101/2025.07.15.662825

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell engulfment defines spatially distinct competitive metabolic niches associated with clinical outcomes in colorectal cancerDOI 10.1101/2025.07.15.662825Read

Cell Competition in Carcinogenesis.Semantic proximity Read

Genomic instability in mutant p53 cancer cells upon entotic engulfment.Semantic proximity Read

Neutrophils escort circulating tumour cells to enable cell cycle progressionSemantic proximity Read

Cancer-Initiating Cells from Colorectal Cancer Patients Escape from T Cell–Mediated Immunosurveillance In Vitro through Membrane-Bound IL-4Semantic proximity Read

KRASG12D mutant cells are outcompeted by wild type neighbours in adult pancreas in an EPHA2-dependent mannerSemantic proximity Read

Cell Fitness: More Than Push-Ups.Semantic proximity Read

Cell Competition During Growth and Regeneration.Semantic proximity Read

Cell Competition Shapes Metastatic Latency and RelapseSemantic proximity Read

Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs).Semantic proximity Read

Immune evasion through competitive inhibition: the shielding effect of cancer non-stem cells.Semantic proximity Read

Cell Competition Spurs Selection of Aggressive Cancer Cells.Semantic proximity Read

A novel computational tool for tracking cancer energy hijacking from immune cellsSemantic proximity Read