Article
Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs).
Proceedings of the National Academy of Sciences of the United States of America - 18 Oct 2016
Bartosh Thomas J, Ullah Mujib, Zeitouni Suzanne, Beaver Joshua, Prockop Darwin J
Abstract excerpt
Patients with breast cancer often develop malignant regrowth of residual drug-resistant dormant tumor cells years after primary treatment, a process defined as cancer relapse. Deciphering the causal basis of tumor dormancy therefore has obvious therapeutic significance. Because cancer cell behavior is strongly influenced by stromal cells, particularly the mesenchymal stem/stromal cells (MSCs) that are actively...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.