Article

KRASG12D mutant cells are outcompeted by wild type neighbours in adult pancreas in an EPHA2-dependent manner

2020-08-04

Abstract excerpt

<h4>Summary</h4> As we age, our tissues are repeatedly challenged by mutational insult, yet cancer occurrence is a relatively rare event. Cells carrying cancer-causing genetic mutations compete with normal neighbours for space and survival in tissues. However, the mechanisms underlying mutant-normal competition in adult tissues and the relevance of this process to cancer remain incompletely understood. Here, we i...

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Literature Corpus work: 281b6671-85cd-5947-b284-1cd46d64b143
DOI: 10.1101/2020.08.04.231050

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