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Article

Cell Competition Spurs Selection of Aggressive Cancer Cells.

Trends in cancer - 1 Sept 2020

Parker Taylor, Madan Esha, Gupta Kartik, Moreno Eduardo, Gogna Rajan

Abstract excerpt

Within heterogeneous tumors, cancer cells are constantly interacting. Cell competition (CC) is a fitness-based selection mechanism that results in increased proliferation of discrete populations at the expense of their less fit neighbors. CC-based selection of fit cells may also drive selection of the most aggressive cancer cells.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32327348
DOI: 10.1016/j.trecan.2020.03.008

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