Article
Cell Competition in Carcinogenesis.
Cancer research - 16 Dec 2022
Madan Esha, Palma António M, Vudatha Vignesh, Trevino Jose G, Natarajan Kedar Nath, Winn Robert A, Won Kyoung Jae, Graham Trevor A, Drapkin Ronny, McDonald Stuart A C, Fisher Paul B, Gogna Rajan
Abstract excerpt
The majority of human cancers evolve over time through the stepwise accumulation of somatic mutations followed by clonal selection akin to Darwinian evolution. However, the in-depth mechanisms that govern clonal dynamics and selection remain elusive, particularly during the earliest stages of tissue transformation. Cell competition (CC), often referred to as 'survival of the fittest' at the cellular level,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.