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Article

Genomic instability in mutant p53 cancer cells upon entotic engulfment.

Nature communications - 3 Aug 2018

Mackay Hannah L, Moore David, Hall Callum, Birkbak Nicolai J, Jamal-Hanjani Mariam, Karim Saadia A, Phatak Vinaya M, Piñon Lucia, Morton Jennifer P, Swanton Charles, Le Quesne John, Muller Patricia A J

Abstract excerpt

Cell-in-cell (CIC) structures are commonly seen in tumours. Their biological significance remains unclear, although they have been associated with more aggressive tumours. Here we report that mutant p53 promotes CIC via live cell engulfment. Engulfed cells physically interfere in cell divisions of host cells and for cells without p53 this leads to host cell death. In contrast, mutant p53 host cells survive,...

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Identifiers

PMID: 30076358
DOI: 10.1038/s41467-018-05368-1
PMCID: PMC6076230

Genes

CIC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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