Article

Chromosome Pairing Through Tensed DNA Tethers Model Revealed by BRCA2 Meiotic Domain Deletion

2023-10-06

Abstract excerpt

<h4>ABSTRACT</h4> BRCA2 has multiple functional domains that interact with different partners, and is essential for both somatic and meiotic homologous recombination (HR). We created a Brca2 Δ12-14 mouse model with an internal deletion of the region which we named “the meiotic domain of BRCA2”, as its loss results in complete failure of meiotic HR, while somatic HR is intact. The deletion in the protein includes...

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Literature Corpus work: 03e72cb8-8711-5d74-8294-196f3bcd0eb1
DOI: 10.1101/2023.10.06.561239

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