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Distinct Properties of the XY Pseudoautosomal Region Crucial for Male Meiosis

17 Feb 2011

Abstract excerpt

Meiosis requires that each chromosome find its homologous partner and undergo at least one crossover. X-Y chromosome segregation hinges on efficient crossing-over in a very small region of homology, the pseudoautosomal region (PAR). We find that mouse PAR DNA occupies unusually long chromosome axes, potentially as shorter chromatin loops, predicted to promote double-strand break (DSB) formation. Most PARs show...

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PMID: 21330546
DOI: 10.1126/science.1195774

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