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DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosis

16 May 2010

Abstract excerpt

Chromosome pairing and synapsis during meiotic prophase requires the formation and repair of DNA double-strand breaks (DSBs) by the topoisomerase-like enzyme SPO11. Chromosomes, or chromosomal regions, that lack a pairing partner, such as the largely heterologous X and Y chromosomes, show delayed meiotic DSB repair and are transcriptionally silenced. Herein, we review meiosis-specific aspects of DSB repair in...

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PMID: 20364103
DOI: 10.4161/epi.5.4.11518

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