Genomic evolution of pancreatic cancer at single-cell resolution

Abstract excerpt

We adapted a previously developed targeted single-nucleus DNA sequencing (snDNA-seq) method and constructed a new suite of computational analysis tools to study 137,491 single-nucleus DNA libraries from 24 pancreatic cancers collected under a variety of clinical scenarios including early and late diagnoses, different metastatic sites and before- and after-treatment. We refined the mutational landscape of pancreati...

Topics

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• BRCA2 Protein
• Carcinoma, Pancreatic Ductal
• Clonal Evolution
• DNA Copy Number Variations
• Germ-Line Mutation
• Pancreatic Neoplasms
• Proto-Oncogene Proteins p21(ras)
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

03d83321-a4c8-573b-bc5c-988ca6d96204

DOI

10.1101/2024.08.03.605165