Translational genomics in pancreatic ductal adenocarcinoma: A review with re-analysis of TCGA dataset.

doi:10.1016/j.semcancer.2018.04.004

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Article

Translational genomics in pancreatic ductal adenocarcinoma: A review with re-analysis of TCGA dataset.

Seminars in cancer biology - 1 Apr 2019

Ho Jeffery, Li Xianchun, Zhang Lin, Liang Yonghao, Hu Wei, Yau Johnny C W, Chan Hung, Gin Tony, Chan Matthew T V, Tse Gary, Wu William K K

Abstract excerpt

Malignancy of the pancreas is a leading cause of cancer-related mortality, with the highest case-fatality of all cancers. Nevertheless, the lack of sensitive biomarkers and presence of biological heterogeneity precludes its early detection and effective treatment. The recent introduction of next-generation sequencing allows characterization of multiple driver mutations at genome- and exome-wide levels. Sequencing...

Topics

Adenocarcinoma
Biomarkers, Tumor
Carcinogenesis
Carcinoma, Pancreatic Ductal
Exome
Gene Expression Regulation, Neoplastic
Genomics
Humans
Mutation
Translational Research, Biomedical

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Open in PubMed

Identifiers

PMID: 29705685
DOI: 10.1016/j.semcancer.2018.04.004

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