Article
Translational genomics in pancreatic ductal adenocarcinoma: A review with re-analysis of TCGA dataset.
Seminars in cancer biology - 1 Apr 2019
Ho Jeffery, Li Xianchun, Zhang Lin, Liang Yonghao, Hu Wei, Yau Johnny C W, Chan Hung, Gin Tony, Chan Matthew T V, Tse Gary, Wu William K K
Abstract excerpt
Malignancy of the pancreas is a leading cause of cancer-related mortality, with the highest case-fatality of all cancers. Nevertheless, the lack of sensitive biomarkers and presence of biological heterogeneity precludes its early detection and effective treatment. The recent introduction of next-generation sequencing allows characterization of multiple driver mutations at genome- and exome-wide levels. Sequencing...
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