Article
Genomic evolution of pancreatic cancer at single-cell resolution.
Nature genetics - 1 Feb 2026
Zhang Haochen, Sashittal Palash, Karnoub Elias-Ramzey, Jakatdar Akhil, Umeda Shigeaki, Hong Jungeui, Noronha Anne Marie, Cardenas Agustin, Erakky Amanda, McIntyre Caitlin A, Hayashi Akimasa, Lecomte Nicolas, Hilmi Marc, Park Wungki, Pang Nan, O'Reilly Eileen M, Wei Alice C, Raphael Benjamin J, Iacobuzio-Donahue Christine A
Abstract excerpt
Most evolutionary studies on pancreatic cancer rely on bulk sequencing, yet clonal evolution happens at the single-cell level. We used single-nucleus DNA sequencing to study 137,491 single nuclei from 24 pancreatic neoplasms reflecting various clinical scenarios. We found higher frequencies of somatic alterations to driver genes that bulk studies indicate; many manifest as copy number alterations and account for...
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