Article

Application of high-throughput, high-depth, targeted single-nucleus DNA sequencing in pancreatic cancer

2022-03-07

Abstract excerpt

Despite insights gained by bulk DNA sequencing of cancer it remains challenging to resolve the admixture of normal and tumor cells, and/or of distinct tumor subclones; high throughput single-cell DNA sequencing circumvents these and brings cancer genomic studies to higher resolution. However, its application has been limited to liquid tumors or a small batch of solid tumors, mainly because of the lack of a scalabl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 42e4a495-5b9b-5a30-8fd3-6c7281c82e64
DOI: 10.1101/2022.03.06.483206

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Application of high-throughput, high-depth, targeted single-nucleus DNA sequencing in pancreatic cancerDOI 10.1101/2022.03.06.483206Read

Application of high-throughput single-nucleus DNA sequencing in pancreatic cancerSemantic proximity Read

Application of high-throughput, high-depth, targeted single-nucleus DNA sequencing in pancreatic cancerSemantic proximity Read

Genomic evolution of pancreatic cancer at single-cell resolutionSemantic proximity Read

Genomic evolution of pancreatic cancer at single-cell resolution.Semantic proximity Read

snPATHO-seq: unlocking the FFPE archives for single nucleus RNA profilingSemantic proximity Read

Single-cell RNA sequencing in pancreatic cancerSemantic proximity Read

Refining the Molecular Framework for Pancreatic Cancer with Single-cell and Spatial TechnologiesSemantic proximity Read

A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumorsSemantic proximity Read

Improved Protocol for Single-Nucleus RNA-sequencing of Frozen Human Bladder Tumor BiopsiesSemantic proximity Read

A single-cell and single-nucleus RNA-seq toolbox for fresh and frozen human tumorsSemantic proximity Read

Precision oncology using a limited number of cells: optimization of whole genome amplification products for sequencing applications.Semantic proximity Read

Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatmentSemantic proximity Read