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Article

ACT-Discover: identifying karyotype heterogeneity in pancreatic cancer evolution using ctDNA.

Genome medicine - 20 Apr 2023

Huebner Ariana, Black James R M, Sarno Francesca, Pazo Roberto, Juez Ignacio, Medina Laura, Garcia-Carbonero Rocio, Guillén Carmen, Feliú Jaime, Alonso Carolina, Arenillas Carlota, Moreno-Cárdenas Ana Belén, Verdaguer Helena, Macarulla Teresa, Hidalgo Manuel, McGranahan Nicholas, Toledo Rodrigo A

Abstract excerpt

BACKGROUND: Liquid biopsies and the dynamic tracking of somatic mutations within circulating tumour DNA (ctDNA) can provide insight into the dynamics of cancer evolution and the intra-tumour heterogeneity that fuels treatment resistance. However, identifying and tracking dynamic changes in somatic copy number alterations (SCNAs), which have been associated with poor outcome and metastasis, using ctDNA is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37081523
DOI: 10.1186/s13073-023-01171-w
PMCID: PMC10120117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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