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Application of high-throughput single-nucleus DNA sequencing in pancreatic cancer

10 Feb 2023

Abstract excerpt

Despite insights gained by bulk DNA sequencing of cancer it remains challenging to resolve the admixture of normal and tumor cells, and/or of distinct tumor subclones; high-throughput single-cell DNA sequencing circumvents these and brings cancer genomic studies to higher resolution. However, its application has been limited to liquid tumors or a small batch of solid tumors, mainly because of the lack of a...

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PMID: 36765116
DOI: 10.1038/s41467-023-36344-z

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