Article
Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution.
Nature genetics - 1 Feb 2020
Chan-Seng-Yue Michelle, Kim Jaeseung C, Wilson Gavin W, Ng Karen, Figueroa Eugenia Flores, O'Kane Grainne M, Connor Ashton A, Denroche Robert E, Grant Robert C, McLeod Jessica, Wilson Julie M, Jang Gun Ho, Zhang Amy, Dodd Anna, Liang Sheng-Ben, Borgida Ayelet, Chadwick Dianne, Kalimuthu Sangeetha, Lungu Ilinca, Bartlett John M S, Krzyzanowski Paul M, Sandhu Vandana, Tiriac Hervé, Froeling Fieke E M, Karasinska Joanna M, Topham James T, Renouf Daniel J, Schaeffer David F, Jones Steven J M, Marra Marco A, Laskin Janessa, Chetty Runjan, Stein Lincoln D, Zogopoulos George, Haibe-Kains Benjamin, Campbell Peter J, Tuveson David A, Knox Jennifer J, Fischer Sandra E, Gallinger Steven, Notta Faiyaz
Abstract excerpt
Pancreatic adenocarcinoma presents as a spectrum of a highly aggressive disease in patients. The basis of this disease heterogeneity has proved difficult to resolve due to poor tumor cellularity and extensive genomic instability. To address this, a dataset of whole genomes and transcriptomes was generated from purified epithelium of primary and metastatic tumors. Transcriptome analysis demonstrated that molecular...
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