A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns.

doi:10.1038/nature19823

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Article

A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns.

Nature - 20 Oct 2016

Notta Faiyaz, Chan-Seng-Yue Michelle, Lemire Mathieu, Li Yilong, Wilson Gavin W, Connor Ashton A, Denroche Robert E, Liang Sheng-Ben, Brown Andrew M K, Kim Jaeseung C, Wang Tao, Simpson Jared T, Beck Timothy, Borgida Ayelet, Buchner Nicholas, Chadwick Dianne, Hafezi-Bakhtiari Sara, Dick John E, Heisler Lawrence, Hollingsworth Michael A, Ibrahimov Emin, Jang Gun Ho, Johns Jeremy, Jorgensen Lars G T, Law Calvin, Ludkovski Olga, Lungu Ilinca, Ng Karen, Pasternack Danielle, Petersen Gloria M, Shlush Liran I, Timms Lee, Tsao Ming-Sound, Wilson Julie M, Yung Christina K, Zogopoulos George, Bartlett John M S, Alexandrov Ludmil B, Real Francisco X, Cleary Sean P, Roehrl Michael H, McPherson John D, Stein Lincoln D, Hudson Thomas J, Campbell Peter J, Gallinger Steven

Abstract excerpt

Pancreatic cancer, a highly aggressive tumour type with uniformly poor prognosis, exemplifies the classically held view of stepwise cancer development. The current model of tumorigenesis, based on analyses of precursor lesions, termed pancreatic intraepithelial neoplasm (PanINs) lesions, makes two predictions: first, that pancreatic cancer develops through a particular sequence of genetic alterations (KRAS,...

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Identifiers

PMID: 27732578
DOI: 10.1038/nature19823
PMCID: PMC5446075

Genes

KRAS
SMAD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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