Article
Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer.
Cancer discovery - 1 Feb 2016
Roberts Nicholas J, Norris Alexis L, Petersen Gloria M, Bondy Melissa L, Brand Randall, Gallinger Steven, Kurtz Robert C, Olson Sara H, Rustgi Anil K, Schwartz Ann G, Stoffel Elena, Syngal Sapna, Zogopoulos George, Ali Syed Z, Axilbund Jennifer, Chaffee Kari G, Chen Yun-Ching, Cote Michele L, Childs Erica J, Douville Christopher, Goes Fernando S, Herman Joseph M, Iacobuzio-Donahue Christine, Kramer Melissa, Makohon-Moore Alvin, McCombie Richard W, McMahon K Wyatt, Niknafs Noushin, Parla Jennifer, Pirooznia Mehdi, Potash James B, Rhim Andrew D, Smith Alyssa L, Wang Yuxuan, Wolfgang Christopher L, Wood Laura D, Zandi Peter P, Goggins Michael, Karchin Rachel, Eshleman James R, Papadopoulos Nickolas, Kinzler Kenneth W, Vogelstein Bert, Hruban Ralph H, Klein Alison P
Abstract excerpt
UNLABELLED: Pancreatic cancer is projected to become the second leading cause of cancer-related death in the United States by 2020. A familial aggregation of pancreatic cancer has been established, but the cause of this aggregation in most families is unknown. To determine the genetic basis of susceptibility in these families, we sequenced the germline genomes of 638 patients with familial pancreatic cancer and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.