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Article

Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression.

Science (New York, N.Y.) - 7 Mar 2014

Fairfax Benjamin P, Humburg Peter, Makino Seiko, Naranbhai Vivek, Wong Daniel, Lau Evelyn, Jostins Luke, Plant Katharine, Andrews Robert, McGee Chris, Knight Julian C

Abstract excerpt

To systematically investigate the impact of immune stimulation upon regulatory variant activity, we exposed primary monocytes from 432 healthy Europeans to interferon-γ (IFN-γ) or differing durations of lipopolysaccharide and mapped expression quantitative trait loci (eQTLs). More than half of cis-eQTLs identified, involving hundreds of genes and associated pathways, are detected specifically in stimulated...

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PMID: 24604202
DOI: 10.1126/science.1246949
PMCID: PMC4064786

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CARD9

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