The identification of blood-derived response eQTLs reveals complex effects of regulatory variants on inflammatory and infectious disease risk.

doi:10.1371/journal.pgen.1011599

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Article

The identification of blood-derived response eQTLs reveals complex effects of regulatory variants on inflammatory and infectious disease risk.

PLoS genetics - 1 Apr 2025

Liefferinckx Claire, Stern David, Perée Hélène, Bottieau Jérémie, Mayer Alice, Dubussy Christophe, Quertinmont Eric, Tafciu Vjola, Minsart Charlotte, Petrov Vyacheslav, Kvasz Alex, Coppieters Wouter, Karim Latifa, Rahmouni Souad, Georges Michel, Franchimont Denis

Abstract excerpt

Hundreds of risk loci for immune mediated inflammatory and infectious diseases have been identified by genome-wide association studies (GWAS). Yet, what causal variants and genes in risk loci underpin the observed associations remains poorly understood for most. The identification of colocalized cis-expression Quantitative Trait Loci (cis-eQTLs) is a promising way to identify candidate causative genes. The...

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Topics

Humans
Quantitative Trait Loci
Genome-Wide Association Study
COVID-19
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

SARS-CoV-2

Arthritis, Rheumatoid

Inflammatory Bowel Diseases

Polymorphism, Single Nucleotide

Inflammation

Transcriptome

Toll-Like Receptors

Female

Male

Communicable Diseases

Source

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Identifiers

PMID: 40208878
DOI: 10.1371/journal.pgen.1011599
PMCID: PMC12013874

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