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Article

Pathogen-specific innate immune response patterns are distinctly affected by genetic diversity.

Nature communications - 5 Jun 2023

Häder Antje, Schäuble Sascha, Gehlen Jan, Thielemann Nadja, Buerfent Benedikt C, Schüller Vitalia, Hess Timo, Wolf Thomas, Schröder Julia, Weber Michael, Hünniger Kerstin, Löffler Jürgen, Vylkova Slavena, Panagiotou Gianni, Schumacher Johannes, Kurzai Oliver

Abstract excerpt

Innate immune responses vary by pathogen and host genetics. We analyze quantitative trait loci (eQTLs) and transcriptomes of monocytes from 215 individuals stimulated by fungal, Gram-negative or Gram-positive bacterial pathogens. We identify conserved monocyte responses to bacterial pathogens and a distinct antifungal response. These include 745 response eQTLs (reQTLs) and corresponding genes with...

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Identifiers

PMID: 37277347
DOI: 10.1038/s41467-023-38994-5
PMCID: PMC10241821

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