Article

Comparative modes of chromatin engagement by PAX::FOXO1 fusions in rhabdomyosarcoma

2026-02-19

Abstract excerpt

<h4>SUMMARY</h4> Fusion positive rhabdomyosarcoma (FP-RMS) is an aggressive soft-tissue sarcoma that most frequently affects children and adolescents. Treatment options and outcomes for children with this cancer remain poor, non-specific, and broadly toxic despite decades of research. The defining molecular drivers of the more aggressive fusion-positive subtype of the disease arise from chromosomal translocations...

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Literature Corpus work: 1a7ed800-0beb-557e-b753-ad009597d7b4
DOI: 10.64898/2026.02.18.706582

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