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The ESCRT protein CHMP5 promotes T cell leukemia by controlling BRD4-p300-dependent transcription

2024-01-31

Abstract excerpt

<h4>Summary</h4> Oncogene activity rewires cellular transcription, creating new transcription networks to which cancer cells become addicted, by mechanisms that are still poorly understood. Using human and mouse models of T cell acute lymphoblastic leukemia (T-ALL), we identify an essential nuclear role for CHMP5, a cytoplasmic endosomal sorting complex required for transport (ESCRT) protein, in establishing and...

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Literature Corpus work
5b0b1fca-bba0-550a-9861-89914d5b36a1
DOI
10.1101/2024.01.29.577409
Open publication

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The ESCRT protein CHMP5 promotes T cell leukemia by controlling BRD4-p300-dependent transcriptionDOI 10.1101/2024.01.29.577409
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