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Article

A three-dimensional ex vivo model recapitulates in vivo features and drug resistance phenotypes in childhood acute lymphoblastic leukemia.

Leukemia - 1 Dec 2025

Kanari Magdalini, Jimenez Garcia Iria, Steffen Fabio D, Krattiger Lisa A, Bataclan Charles, Liu Wangjie, Simona Benjamin R, Deplancke Bart, Naveiras Olaia, Ehrbar Martin, Bornhauser Beat, Bourquin Jean-Pierre

Abstract excerpt

Acute lymphoblastic leukemia (ALL) preferentially localizes in the bone marrow (BM) and displays recurrent patterns of medullary and extra-medullary involvement. Leukemic cells exploit their niche for propagation and survive selective pressure by chemotherapy in the BM microenvironment, suggesting the existence of protective mechanisms. Here, we established a three-dimensional (3D) BM mimic with human mesenchymal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40931046
DOI: 10.1038/s41375-025-02739-8
PMCID: PMC12634434

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