Article

NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization

2022-02-25

Abstract excerpt

<h4>ABSTRACT</h4> The NSD2 p.E1099K (EK) mutation has been shown to be enriched in patients with relapsed ALL and found to play a role in clonal fitness dependent on the underlying genetic/epigenetic landscape of the cells. To uncover 3D chromatin architecture-related mechanisms underlying drug resistance, we systematically integrated Hi-C, ATAC-seq, RNA-seq and ChIP-seq data from three B-ALL cell lines heterozyg...

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Literature Corpus work: e90a54e7-c730-5bec-b7b3-2bf4bf8760df
DOI: 10.1101/2022.02.24.481835

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