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Melanoma-Derived DNA Polymerase Theta Variants Exhibit Altered DNA Polymerase Activity.

Biochemistry - 7 May 2024

Thomas Corey, Avalos-Irving Lisbeth, Victorino Jorge, Green Sydney, Andrews Morgan, Rodrigues Naisha, Ebirim Sarah, Mudd Ayden, Towle-Weicksel Jamie B

Abstract excerpt

DNA polymerase θ (Pol θ or POLQ) is primarily involved in repairing double-stranded breaks in DNA through an alternative pathway known as microhomology-mediated end joining (MMEJ) or theta-mediated end joining (TMEJ). Unlike other DNA repair polymerases, Pol θ is thought to be highly error-prone yet critical for cell survival. We have identified several POLQ gene variants from human melanoma tumors that...

Topics

Humans
DNA Polymerase theta
DNA-Directed DNA Polymerase
Melanoma
DNA Repair
Mutation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38671548
DOI: 10.1021/acs.biochem.3c00670
PMCID: PMC11080051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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