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Article

Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining.

Nature reviews. Molecular cell biology - 1 Feb 2022

Ramsden Dale A, Carvajal-Garcia Juan, Gupta Gaorav P

Abstract excerpt

Cellular pathways that repair chromosomal double-strand breaks (DSBs) have pivotal roles in cell growth, development and cancer. These DSB repair pathways have been the target of intensive investigation, but one pathway - alternative end joining (a-EJ) - has long resisted elucidation. In this Review, we highlight recent progress in our understanding of a-EJ, especially the assignment of DNA polymerase theta...

Topics

Animals
DNA End-Joining Repair
DNA Replication
DNA-Directed DNA Polymerase
Humans
Models, Biological
Mutation
Neoplasms
DNA Polymerase theta

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34522048
DOI: 10.1038/s41580-021-00405-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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