Article

Melanoma-derived DNA polymerase theta variants exhibit altered DNA polymerase activity

2023-11-14

Abstract excerpt

DNA Polymerase θ (Pol θ or POLQ) is primarily involved in repairing double-stranded breaks in DNA through the alternative pathway known as microhomology-mediated end joining (MMEJ) or theta-mediated end joining (TMEJ). Unlike other DNA repair polymerases, Pol θ is thought to be highly error prone, yet critical for cell survival. We have identified several mutations in the POLQ gene from human melanoma tumors. Thro...

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Literature Corpus work: 8c22afad-936c-57f2-ad10-71c348001145
DOI: 10.1101/2023.11.14.566933

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