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Targeting the DNA Repair Enzyme Polymerase θ in Cancer Therapy

24 Oct 2020

Abstract excerpt

Targeted cancer therapies represent a milestone towards personalized treatment as they function via inhibition of cancer-specific alterations. Polymerase θ (POLQ), an error-prone translesion polymerase, also involved in DNA double-strand break (DSB) repair, is often upregulated in cancer. POLQ is synthetic lethal with various DNA repair genes, including known cancer drivers such as BRCA1/2, making it essential in...

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PMID: 33109489
DOI: 10.1016/j.trecan.2020.09.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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