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Genetic determinants of cellular addiction to DNA polymerase theta

19 Sept 2019

Abstract excerpt

Polymerase theta (Pol θ, gene name Polq) is a widely conserved DNA polymerase that mediates a microhomology-mediated, error-prone, double strand break (DSB) repair pathway, referred to as Theta Mediated End Joining (TMEJ). Cells with homologous recombination deficiency are reliant on TMEJ for DSB repair. It is unknown whether deficiencies in other components of the DNA damage response (DDR) also result in Pol θ...

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PMID: 31537809
DOI: 10.1038/s41467-019-12234-1

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