Article

Membrane protein sequence features direct post-translational insertion

2023-12-12

Abstract excerpt

The proper folding of multispanning membrane proteins (MPs) hinges on the accurate insertion of their transmembrane helices (TMs) into the membrane. Predominantly, TMs are inserted during protein translation, via a conserved mechanism centered around the Sec translocon. Our study reveals that the C-terminal TMs (cTMs) of numerous MPs across various organisms bypass this cotranslational route, necessitating an alte...

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Literature Corpus work: feaf364f-b479-570f-8e7d-9ba664ab4e41
DOI: 10.1101/2023.12.12.571264

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