Article

The ER membrane protein complex acts as a chaperone to promote the biogenesis of multi-bundle membrane proteins

2026-01-15

Abstract excerpt

<h4>SUMMARY</h4> Nearly half of the ∼5,000 human membrane proteins need to assemble into stoichiometric complexes as part of their biogenesis at the endoplasmic reticulum (ER) membrane. How ER resident biogenesis factors coordinate membrane insertion, folding and assembly is not well understood. Here, we demonstrate that the ER membrane protein complex (EMC) insertase additionally acts as a chaperone to facilitat...

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Literature Corpus work: 543acadf-f6a7-50bd-af77-2a31ce9affb2
DOI: 10.64898/2026.01.14.699575

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