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Article

Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins

2023-11-29

Abstract excerpt

<h4>SUMMARY</h4> Mammalian membrane proteins perform essential physiologic functions that rely on their accurate insertion and folding at the endoplasmic reticulum (ER). Using forward and arrayed genetic screens, we systematically studied the biogenesis of a panel of membrane proteins, including several G-protein coupled receptors (GPCRs). We observed a central role for the insertase, the ER membrane protein comp...

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Literature Corpus work
0cf9ab3a-5e0a-503a-b04d-b9fcb55c7ffd
DOI
10.1101/2023.11.28.569054
Open publication

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Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteinsDOI 10.1101/2023.11.28.569054
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