Article

Regulated assembly of the ER membrane protein complex

2020-07-21

Abstract excerpt

<h4>Summary</h4> The assembly of nascent proteins into multi-subunit complexes is tightly regulated to maintain cellular homeostasis. The ER membrane protein complex (EMC) is an essential insertase that requires seven membrane-spanning and two soluble subunits for function. Here we show that the kinase With no lysine 1 (WNK1), known for its role in hypertension and neuropathy, is required for assembly of the huma...

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Literature Corpus work: 44332480-a95c-5df9-9b37-6311395c3ae7
DOI: 10.1101/2020.07.20.213066

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