Article

Targeted RNA editing by direct delivery of an adenosine deaminase-antisense oligo conjugate

2025-07-12

Abstract excerpt

<h4>ABSTRACT</h4> Programmable RNA editing is a promising therapeutic strategy for correcting disease-causing mutations on mRNA, but current approaches rely primarily upon endogenous RNA editing enzymes (i.e. ADARs) that have restricted substrate scope and efficiency. Here, we demonstrate programmable RNA editing with evolved TadA-derived deaminases and 2’-methoxyethyl (MOE)-modified antisense oligonucleotides (A...

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Literature Corpus work: 97eb79a3-3bf0-51f9-9985-1b1a0d14c704
DOI: 10.1101/2025.07.11.664364

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