Article

Robust RNA editing via recruitment of endogenous ADARs using circular guide RNAs

2021-01-13

Abstract excerpt

<h4>ABSTRACT</h4> Akin to short-hairpin RNAs and antisense oligonucleotides which efficaciously recruit endogenous cellular machinery such as Argonaute and RNase H to enable targeted RNA knockdown, simple long antisense guide RNAs ( 1 ) can recruit endogenous adenosine deaminases acting on RNA (ADARs) to enable programmable A-to-I RNA editing, without requiring co-delivery of any exogenous proteins. This approac...

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Literature Corpus work: 63caa7a0-15e3-558e-a61c-153a198e7e06
DOI: 10.1101/2021.01.12.426286

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