Article

Leveraging Endogenous ADAR for Programmable Editing on RNA

2019-04-19

Abstract excerpt

Nucleic acid editing carries enormous potential for biological research and the development of therapeutics. Current tools for DNA or RNA editing rely on introducing exogenous proteins into living organisms, which is subject to potential risks or technical barriers due to possible aberrant effector activity, delivery limits and immunogenicity. Here, we report a programmable approach that employs a short RNA to lev...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 01bb0309-aefe-504f-b780-dbdab8289481
DOI: 10.1101/605972

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Leveraging Endogenous ADAR for Programmable Editing on RNADOI 10.1101/605972Read

Targeted RNA editing by direct delivery of an adenosine deaminase-antisense oligo conjugateSemantic proximity Read

RNA editing with CRISPR-Cas13Semantic proximity Read

Robust RNA editing via recruitment of endogenous ADARs using circular guide RNAsSemantic proximity Read

RNA-Guided Adenosine Deaminases: Advances and Challenges for Therapeutic RNA EditingSemantic proximity Read

A cytosine deaminase for programmable single-base RNA editingSemantic proximity Read

A Novel Engineered U7 Small Nuclear RNA Scaffold Greatly Increases <i>in vitro</i> and <i>in vivo</i> ADAR-Mediated Programmable RNA Base EditingSemantic proximity Read

REPAIRx, a specific yet highly efficient programmable A > I RNA base editor.Semantic proximity Read

Site-directed RNA editing by adenosine deaminase acting on RNA for correction of the genetic code in gene therapy.Semantic proximity Read

Programmable RNA base editing with a single gRNA-free enzymeSemantic proximity Read

An engineered U7 small nuclear RNA scaffold greatly increases ADAR-mediated programmable RNA base editingSemantic proximity Read

A systematic evaluation of the therapeutic potential of endogenous-ADAR editors in cancer prevention and treatment.Semantic proximity Read

Modular and programmable RNA sensing using ADAR editing in living cellsSemantic proximity Read